Substances led to Psychosis: A Systematic Review

The Open Psychology Journal 30 May 2024 SYSTEMATIC REVIEW DOI: 10.2174/0118743501297735240510161825



Psychosis is one of the mind-related disorders that has been common in the new generation, and it has an increasing trend. Psychosis is a variable feature of mood that could be a result of substance use, which includes a few psychiatric and neurologic symptoms. Common symptoms of psychoses are delusions, hallucinations, disorganized thinking, grossly disorganized, or abnormal motor behavior. An array of illicit substances and drugs that can lead to psychosis include cannabinoids, cocaine, amphetamines, methamphetamines, alcohol, etc.


The main aim of this review was to discover, analyze, and combine the information concerning substances that could potentially cause psychoses.


We conducted a literature search on the following network databases: PubMed, Scholar, Science Direct, PubChem, Scopus, and Web-Of-Science. We selected 14 studies potentially relevant articles published from 1990 to 2023 for detailed evaluation. The systematic review was done adhering to PRISMA guidelines. We gathered the important primary studies of eligible systematic reviews and collected data on the interventions employed in these studies to comprehend the strategies that were pursued.


Our result indicated that there are a few substances, which include Cannabinoids, Alcohol, Amphetamine, Cocaine, Nicotine, Kratom, Cathinone, etc., that may lead to psychoses with average to high possibility.


Evidence regarding frequently encountered substances that might contribute to psychosis presents an opportunity to develop customized interventions in the form of user-friendly menus aimed at meeting individuals' requirements and urging them to refrain from consumption.

Keywords: Psychosis, Illicit drugs, Youth, Antibiotics, Neurologic symptoms, Alcohol.
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